VDR is a gene which codes for a vitamin D receptor protein. This protein regulates calcium absorption as well as bone development. A variant of the gene (rs2228570, FokI polymorphism) is associated with a reduced bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by two components, and is influenced by chromosomal locations and by binding preferences for specific hormones. Microarray studies of human cells reveal that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository of data and documents that are relevant to legal transactions, business or other activities that have limitations on viewing or downloading. It uses central computers and an extranet that is a restricted-access Internet connection, allowing users to log in at specified times.
VDRs are primarily used by investment banks and companies involved in mergers or acquisitions. They require an efficient and secure platform to share information with investors or buyers in a manner that is transparent, and due diligence could require huge amounts of data. Life science companies also make use of VDRs for everything from clinical trials results to HIPAA compliance documents.
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